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Large Scale Screening via Gain-of-Function 
The application of a broad range of cDNAs and derivative products (shRNA, antibodies) enables scientists to better validate and choose targets that are most relevant to disease processes. Some recent publications describing these methods are listed below for your convenience.
Large Scale Functional Profiling Using cDNA Clone Collections:
A pathway sensor for genome-wide screens of intracellular proteolytic cleavage. Genome Biol. 2008 Apr
A functional genomics approach to the mode of action of apratoxin A Nature Chemical Biology.2007
A genomic screen for activators of the antioxidant response element Proc. Natl. Acad. Sci. 2007
Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1 alpha transcription and mitochondrial biogenesis in muscle cells Proc. Natl. Acad. Sci. 2006
Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis
Proc. Natl. Acad. Sci. 2005
High throughput functional genomics: identification of novel genes with tumor suppressor phenotypes.
Int J Cancer 2005 (Use of over 17,000 genes)
High-throughput Functional Genomics Identifies Genes That Ameliorate Toxicity Due to Oxidative Stress in Neuronal HT-22 Cells: GFPT2 Protects Cells Against Peroxide
Mol. Cell. Proteomics 2004 (Use of 5,000 genes, including OriGene's TrueClones)
Identification of p53 regulators by genome-wide functional analysis
PNAS 2004 (Use of 20,000 genes)
Genome-scale functional profiling of the mammalian AP-1 signaling pathway.
PNAS 2003 (Use of 20,000 genes)
Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells.
PNAS 2003 (Use of 20,000 genes)
An integrated functional genomics screening program reveals a role for BMP-9 in glucose homeostasis.
Nature Biotechnology 2003 (Use of 8,000 genes encoding secreted proteins)
TIP, a T-cell factor identified using high-throughput screening increases survival in a graft-versus-host disease model. (Use of 8,000 ESTs encoding putative secreted proteins)
Nature Biotechnology 2003
Large Scale Functional Profiling Using shRNA Expression Constructs:
A resource for large-scale RNA-interference-based screens in mammals.
Nature 2004: (Use of 28,000 shRNA expression cassette)
A large-scale RNAi screen in human cells identifies new components of the p53 pathway.
Nature 2004 (Use of 23,742 shRNA constructs targeting 7,914 genes)
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