TrueMAB™ Antibodies - Made against Authentic Protein Antigens

The improvements of sensitivity and specificity of immunoassays are critical to advance proteomic studies. It demands high quality antibodies for the detection of native epitopes of endogenous proteins.

OriGene has developed TrueMAB™ antibodies to advance the performance of immunoassays.

• Superior monoclonal antibodies recognize native epitopes of proteins’ native conformations
• Made against authentic protein antigens
• Extensive validations
  • Western blot on overexpression cell lysate
  • Western blot on a panel of at least 7 different cell lines
  • IHC on up to 24 unique normal and disease-state FFPE human tissues
  • Immunofluorescent staining
  • Flow cytometry

TrueMAB™ antibodies were generated using recombinant human proteins as antigens (most of them are full length proteins expressed in human cell lines) that were affinity purified under native condition to preserve the protein conformations. The commonly available commercial antibodies were generated using short peptides. The peptide antigens are inadequate to mimic the protein conformations due to the lack of three-dimensional structures. In particular, peptide-derived antibodies cannot recognize conformational epitopes which are abundant on the surfaces of native proteins.

In comparison to peptide-derived antibodies, TrueMAB™ antibodies provide high sensitivity and specificity for the recognition of native epitopes appeared on the protein conformational structures. They are great tools for immunoassays that are sensitive to proteins conformations, such as immunofluorescence, immunoprecipitation, immunohistochemistry, flow cytometry, ELISA, antibody arrays and more

We are adding new TrueMAB™ antibodies against human proteins to our product list every month. For further questions, please send emails to antibody@origene.com or contact our technical supports

Nominate your favorite human protein antigen(s) for TrueMAB™ monoclonal antibody collection

OriGene Raised $16 M to build TrueMAB™ collection, learn more >>

World’s largest TrueMAB™ monoclonal antibody facility, learn more >>

TrueMAB™ join-development programs are available for monoclonal antibody development. more >>

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